Uggh, finally grew the region past 500,000 population. From what I'm seeing, there's a definite population cap at 20k for a city - unless you add health and education items. (I've got more then a few cities that are capped at 20k.) I'm even beginning to suspect that there's a 5k cap if you don't have water pipes (maybe 10k?). I notice that residences will only develop to the single-double family homes when relying on well water.
At 120k, my South Bend city was awarded a movie studio... (the mayor refused to comment on whether he was going to be starring in any upcoming movies).